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Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A

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  • Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A

Alzheimer’s disease (AD) is recognized as one of the most common forms of senile dementia (Qiu et al., 2007). AD begins with memory loss of recent events (short-term memory impairment) and finally robs the patients of their sense of self (Amemori et al., 2015). Early onset of the disease, older age, low education level, and several poor health conditions affect the prevalence rate of the disease and the degree of cognitive impairment (de Souza-Talarico et al., 2016). Increased biomarkers of oxidative stress (Furman et al., 2016), inflammation and chronic neuroinflammation are reported to be associated with many neurodegenerative disorders of central nervous system (CNS) including AD (Leszek et al., 2016). Furthermore, previous studies have demonstrated that metabolic alterations such as insulin resistance (Arrieta-Cruz and Gutierrez-Juarez, 2016),  hyperglycemia (Arrieta-Cruz and Gutierrez-Juarez, 2016), and dyslipidemia (Presecki et al., 2011) are associated with the pathogenesis and development of AD. Experimental  evidence indicates that alterations in micronutrients are also among the risk factors for AD (Taghizadeh et al., 2014).

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